California’s Active Pharmaceutical Ingredient (API) industry stands out as a vital part of the U.S. pharmaceutical landscape, bringing quality and affordable treatments to patients worldwide. These Top 10 API Manufacturers in California are financially strong, thanks to high demand, steady innovation, and a global impact.
API Manufacturers in California
California’s API manufacturing industry boasts some of the world’s largest and most financially robust pharmaceutical companies. With millions to billions in revenue, these companies are not only leaders in the Active Pharmaceutical Ingredient market but also play a significant role in research, innovation, and market growth. Let’s explore these Top 10 API Manufacturers in California, noting their financial health and achievements.
Top 10 API Manufacturers in California
| Rank | Company |
|---|---|
| 1 | Amgen Inc. |
| 2 | Gilead Sciences, Inc. |
| 3 | Genentech (Roche Group) |
| 4 | Avid Bioservices, Inc. |
| 5 | Grifols Biologicals LLC |
| 6 | Impax Laboratories, Inc. |
| 7 | Ligand Pharmaceuticals |
| 8 | Parexel International |
| 9 | BioMarin Pharmaceutical Inc. |
| 10 | Abbott Laboratories |
1. Amgen Inc.
Amgen, a biotech powerhouse, consistently reports high revenues thanks to its leading position in biologics. With annual revenues exceeding $26 billion, Amgen is one of the highest-grossing biotechs globally. Strong R&D investment keeps Amgen at the forefront of innovative biologic APIs.
- Location: Thousand Oaks, CA
- Focus: Biologics and Biosimilars
2. Gilead Sciences, Inc.
Known for antiviral breakthroughs, Gilead has experienced steady financial growth due to its high-demand treatments. Gilead generates over $27 billion in revenue, largely from its antiviral portfolio. With extensive research in antiviral APIs, Gilead is a global leader in critical disease treatment.
- Location: Foster City, CA
- Focus: Antiviral APIs, especially for HIV and Hepatitis
3. Genentech (Roche Group)
As part of Roche, Genentech enjoys strong financial backing, allowing substantial investments in oncology. Roche, Genentech’s parent company, reports around $63 billion in global revenue, with Genentech as a major contributor. Leading in oncology, Genentech is a key player in making advanced cancer treatments accessible.
- Location: South San Francisco, CA
- Focus: Oncology and Immunology
4. Avid Bioservices, Inc.
This API Manufacturer is a smaller but stable company known for its expertise in monoclonal antibody production. Avid reported around $142 million in revenue last year, showing consistent growth in biologics manufacturing. Avid’s client-centered solutions and expertise in monoclonal antibodies attract many biopharma clients.
- Location: Tustin, CA
- Focus: Monoclonal antibodies and Biologics
5. Grifols Biologicals LLC
Grifols, a leader in plasma-derived APIs, enjoys steady revenues from its unique plasma products. With over $6 billion in global revenue, Grifols is one of the leading names in plasma-based pharmaceuticals. Decades of experience in plasma processing position Grifols as a top API supplier for immune and coagulation therapies.
- Location: Los Angeles, CA
- Focus: Plasma-derived APIs
6. Impax Laboratories, Inc.
Known for producing affordable generics, Impax sees stable revenue by making APIs for essential medicines. Now part of Amneal Pharmaceuticals, which has an estimated revenue of over $2 billion, Impax contributes significantly to the generics market. Impax focuses on cost-effective manufacturing, making critical APIs accessible to broader populations.
- Location: Hayward, CA
- Focus: Generic APIs
7. Ligand Pharmaceuticals
This API Manufacturer is a versatile player in small molecule APIs, with a unique business model focusing on licensing and collaborations. Ligand generates around $200 million annually, much of it from partnerships and licensing. Licensing allows Ligand to collaborate globally, expanding its API reach.
- Location: San Diego, CA
- Focus: Small molecule APIs
8. Parexel International
It’s known for its contract manufacturing and clinical trial services, and has strong financial stability. Privately held but estimated to generate over $2 billion, Parexel’s services support a wide range of biopharma needs. Their comprehensive services streamline API production from development to compliance.
- Location: San Diego, CA
- Focus: Contract API manufacturing
9. BioMarin Pharmaceutical Inc.
BioMarin is a leader in rare disease APIs, showing consistent growth due to its focus on underserved patient needs. The company reported around $2 billion in revenue, driven by niche therapies for rare diseases. Their focus on rare conditions brings essential APIs to patients with few treatment options.
- Location: San Rafael, CA
- Focus: Rare Disease APIs
10. Abbott Laboratories
Abbott, a global health leader, has a diverse product range that brings steady revenue across pharmaceutical and nutritional APIs. With total annual revenue exceeding $43 billion, Abbott has a strong presence in both pharma and nutrition sectors. Abbott’s commitment to health and innovation ensures it remains a key API provider for wellness and disease management.
- Location: Alameda, CA
- Focus: Nutritional and Pharmaceutical APIs
What is API?
Active Pharmaceutical Ingredient (API) is the main ingredient in a drug that produces the desired therapeutic effect. APIs can be synthesized through chemical processes or extracted from natural sources (plants, animals, or microorganisms). APIs are regulated by pharmaceutical authorities like the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA), and others.
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